15088107 CAS 957135-43-2: SM-164

CAS 957135-43-2 : SM-164

  • CAS 957135-43-2 : SM-164

CAS 957135-43-2 : SM-164
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 957135-43-2
  • Stock: 427g
  • Assay: 99.34%

SM-164, CAS 957135-43-2

SM-164, CAS 957135-43-2, Stock 427g, Assay 99.34%, White powder, EOS Med Chem is big manufacturer of SM-164.


SM-164

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP-1 and cIAP-2 proteins. It is developed as an anticancer agent. It plays its antitumor roles through inducing degradation of cellular inhibitor of apoptosis protein (cIAP)-1/2, antagonizing X-linked inhibitor of apoptosis protein (XIAP) and inducing TNFα–dependent apoptosis in tumor cells. SM-164 is a bivalent mimetic containing two SM-122 analogues. It binds to cIAP-1 protein containing bothBIR2 and BIR3 domains, cIAP-2 BIR3 protein and XIAP protein containing both BIR2 and BIR3 domains.


Product Details:

Name: SM-164

CAS#: 957135-43-2

Chemical Formula: C62H84N14O6

Exact Mass: 1120.66983

Molecular Weight: 1121.45

Elemental Analysis: C, 66.40; H, 7.55; N, 17.49; O, 8.56


Specification:

Synonym: SM 164; SM164; SM-164.

IUPAC/Chemical Name: (3S,3'S,6S,6'S,10aS,10a'S)-N,N'-((1S,1'S)-((1,4-phenylenebis(butane-4,1-diyl))bis(1H-1,2,3-triazole-1,4-diyl))bis(phenylmethylene))bis(6-((S)-2-(methylamino)propanamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide)

InChi Key: LGYDZXNSSLRFJS-IOQQVAQYSA-N

InChi Code: InChI=1S/C62H84N14O6/c1-41(63-3)57(77)65-49-27-13-11-25-47-33-35-53(75(47)61(49)81)59(79)67-55(45-21-7-5-8-22-45)51-39-73(71-69-51)37-17-15-19-43-29-31-44(32-30-43)20-16-18-38-74-40-52(70-72-74)56(46-23-9-6-10-24-46)68-60(80)54-36-34-48-26-12-14-28-50(62(82)76(48)54)66-58(78)42(2)64-4/h5-10,21-24,29-32,39-42,47-50,53-56,63-64H,11-20,25-28,33-38H2,1-4H3,(H,65,77)(H,66,78)(H,67,79)(H,68,80)/t41-,42-,47-,48-,49-,50-,53-,54-,55-,56-/m0/s1

SMILES Code: O=C1N2[C@@](CC[C@H]2C(N[C@H](C3=CN(CCCCC4=CC=C(CCCCN5N=NC([C@@H](NC([C@H](CC[C@@]6(CCCC7)[H])N6C([C@H]7NC([C@@H](NC)C)=O)=O)=O)C8=CC=CC=C8)=C5)C=C4)N=N3)C9=CC=CC=C9)=O)([H])CCCC[C@@H]1NC([C@H](C)NC)=O

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: