CAS 956274-94-5: Mavatrep
(World's Largest Pharmaceutical Supplier)

Mavatrep, CAS 956274-94-5

Mavatrep, CAS 956274-94-5, Stock 427g, Assay 99.34%, White powder, EOS Med Chem is big manufacturer of Mavatrep.

Mavatrep

Mavatrep, aslo known as JNJ-39439335, is a potent and selective TRPV1 antagonist. . In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, Mavatrep antagonized capsaicin-induced Ca(2+) influx, with an IC50 value of 4.6 nM. In the complete Freund's adjuvant- and carrageenan-induced thermal hypersensitivity models, Mavatrep exhibited full efficacy, with ED80 values of 7.8 and 0.5 mg/kg, respectively, corresponding to plasma levels of 270.8 and 9.2 ng/mL, respectively. On the basis of its superior pharmacologic and safety profile, Mavatrep was selected for clinical development for the treatment of pain.

Product Details:

Name: Mavatrep

CAS#: 956274-94-5

Chemical Formula: C25H21F3N2O

Exact Mass: 422.1606

Molecular Weight: 422.4512

Elemental Analysis: C, 71.08; H, 5.01; F, 13.49; N, 6.63; O, 3.79

Specification:

Synonym: JNJ-39439335; JNJ 39439335; JNJ39439335; Mavatrep.

IUPAC/Chemical Name: (E)-2-(2-(2-(4-(trifluoromethyl)styryl)-1H-benzo[d]imidazol-6-yl)phenyl)propan-2-ol

InChi Key: ORDHXXHTBUZRCN-NTEUORMPSA-N

InChi Code: InChI=1S/C25H21F3N2O/c1-24(2,31)20-6-4-3-5-19(20)17-10-13-21-22(15-17)30-23(29-21)14-9-16-7-11-18(12-8-16)25(26,27)28/h3-15,31H,1-2H3,(H,29,30)/b14-9+

SMILES Code: OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: