CAS 953769-46-5: BLZ945

  • CAS 953769-46-5: BLZ945

CAS 953769-46-5: BLZ945
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 953769-46-5
  • Stock: 323g
  • Assay: 99.34%

BLZ945, CAS 953769-46-5

BLZ945, CAS 953769-46-5, Stock 323g, Assay 99.34%, Off-white powder, EOS Med Chem is big manufacuturer of BLZ945.


BLZ945

BLZ945 is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis.



Product Details:

Name: BLZ945

CAS#: 953769-46-5

Chemical Formula: C20H22N4O3S

Exact Mass: 398.14126

Molecular Weight: 398.48

Elemental Analysis: C, 60.28; H, 5.57; N, 14.06; O, 12.04; S, 8.05



Specification:

Synonym: BLZ945; BLZ 945; BLZ-945.

IUPAC/Chemical Name: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide

InChi Key: ADZBMFGQQWPHMJ-RHSMWYFYSA-N

InChi Code: InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1

SMILES Code: O=C(NC)C1=NC=CC(OC2=CC3=C(N=C(N[C@@H]4CCCC[C@H]4O)S3)C=C2)=C1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: