CAS 929046-33-3: Elinzanetant

CAS 929046-33-3: Elinzanetant, Stock 345g, Assay 99.7%, White powder, Water 0.27%, Single Impurity 0.3%.

Elinzanetant

Elinzanetant is a neurokinin receptors antagonist that may help reduce the frequency and severity of hot flushes during menopause. Elinzanetant reduces Estradiol and Progesterone in Healthy Women. Elinzanetant dose-dependently lowered serum luteinizing hormone, estradiol (120 mg median change across cycle: -141.4 pmol/L, P = .038), and luteal-phase progesterone (120 mg change from baseline on day 21 or 22: -19.400 nmol/L, P = .046). Elinzanetant 120 mg prolonged the cycle length by median of 7.0 days (P = .023). Elinzanetant reduced the proportion of women with a luteal-phase serum progesterone concentration greater than 30 nmol/L (a concentration consistent with ovulation) in a dose-related manner in cycle 2 (P = .002).

Product Details:

Name: Elinzanetant

CAS#: 929046-33-3 (free base)

Chemical Formula: C33H35F7N4O3

Exact Mass: 668.26

Molecular Weight: 668.660

Elemental Analysis: C, 59.28; H, 5.28; F, 19.89; N, 8.38; O, 7.18

Specification:

Related CAS #: 1207428-19-0 (tosylate)   929046-33-3 (free base)   929046-34-4 (1HCl)   1268364-52-8 (2HCl)    

Synonym: Elinzanetant; BAY 3427080; BAY-3427080; BAY3427080; NT 814; NT-814; NT814; GSK1144814A; GSK-1144814A; GSK 1144814A;

IUPAC/Chemical Name: 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]pyridin-3-yl}-N,2-dimethylpropanamide

InChi Key: DWRIJNIPBUFCQS-DQEYMECFSA-N

InChi Code: InChI=1S/C33H35F7N4O3/c1-19-9-23(34)5-6-26(19)27-13-29(44-16-25-18-47-8-7-43(25)15-24(44)17-45)41-14-28(27)42(4)30(46)31(2,3)20-10-21(32(35,36)37)12-22(11-20)33(38,39)40/h5-6,9-14,24-25,45H,7-8,15-18H2,1-4H3/t24-,25-/m0/s1

SMILES Code: CC(C)(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C(N(C2=C(C3=CC=C(F)C=C3C)C=C(N4C[C@@]5([H])COCCN5C[C@H]4CO)N=C2)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001