CAS 897383-62-9: Allitinib free base
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Allitinib free base

Allitinib free base，CAS 897383-62-9， Stock 268g, Assay 99.20%, Off-white or White powder, EOS Med Chem is big manufacturer of Allitinib free base. 

Allitinib free base

Allitinib, also known as AST1306 and ALS 1306, is a potent, selective, irreversible ErbB2 and EGFR inhibitor. AST-1306 inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. In vivo, AST1306 potently suppressed tumor growth in ErbB2-overexpressing adenocarcinoma xenograft and FVB-2/N(neu) transgenic breast cancer mouse models, but weakly inhibited the growth of EGFR-overexpressing tumor xenografts.

Product Details:

Name: Allitinib free base

CAS#: 897383-62-9 (free base)

Chemical Formula: C24H18ClFN4O2

Exact Mass: 448.1102

Molecular Weight: 448.8824

Elemental Analysis: C, 64.22; H, 4.04; Cl, 7.90; F, 4.23; N, 12.48; O, 7.13

Specification:

Synonym: Allitinib free base; AST1306; AST-1306; AST 1306; ALS1306; ALS-1306; ALS1306; AST 6; AST-6; AST6. Allitinib

IUPAC/Chemical Name: N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide

InChi Key: MVZGYPSXNDCANY-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H18ClFN4O2/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15/h2-12,14H,1,13H2,(H,29,31)(H,27,28,30)

SMILES Code: C=CC(NC1=CC2=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)N=CN=C2C=C1)=O

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: