CAS 887936-68-7: Temanogrel

CAS 887936-68-7: Temanogrel
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  • CAS Number: 887936-68-7
  • Stock: 268g
  • Assay: 99.20%

Temanogrel

Temanogrel, CAS 887936-68-7, Stock 268g, Assay 99.20%, Off-white or White powder, EOS Med Chem is big manufacturer of Temanogrel.


Temanogrel

Temanogrel, also known as APD791, is a highly selective 5-hydroxytryptamine2A receptor inverse agonist under development for the treatment of arterial thrombosis. APD791 displayed high-affinity binding to membranes (K(i) = 4.9 nM) and functional inverse agonism of inositol phosphate accumulation (IC(50) = 5.2 nM) in human embryonic kidney cells stably expressing the human 5-HT(2A) receptor. APD791 was greater than 2000-fold selective for the 5-HT(2A) receptor versus 5-HT(2C) and 5-HT(2B) receptors. APD791 inhibited 5-HT-mediated amplification of ADP-stimulated human and dog platelet aggregation (IC(50) = 8.7 and 23.1 nM, respectively).


Product Details:

Name: Temanogrel

CAS#: 887936-68-7

Chemical Formula: C24H28N4O4

Exact Mass: 436.2111

Molecular Weight: 436.512

Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66


Specification:

Synonym: APD791; APD-791; APD 791; Temanogrel

IUPAC/Chemical Name: 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide

InChi Key: ZEOQUKRCASTCFR-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H28N4O4/c1-27-22(8-9-25-27)21-17-19(26-24(29)18-4-3-5-20(16-18)30-2)6-7-23(21)32-15-12-28-10-13-31-14-11-28/h3-9,16-17H,10-15H2,1-2H3,(H,26,29)

SMILES Code: O=C(NC1=CC=C(OCCN2CCOCC2)C(C3=CC=NN3C)=C1)C4=CC=CC(OC)=C4

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: