999330 CAS 587871-26-9: KU-55933

CAS 587871-26-9: KU-55933

  • CAS 587871-26-9: KU-55933

CAS 587871-26-9: KU-55933
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  • CAS Number: 587871-26-9
  • Stock: 370g
  • Assay: 97.00%

CAS 587871-26-9: KU-55933

CAS 587871-26-9: KU-55933, Stock 370g, Assay 99.7%, White powder, Water 0.27%, Single Impurity 0.3%.


KU-55933

 KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. 


Product Details:

Name: KU-55933

CAS#: 587871-26-9

Chemical Formula: C21H17NO3S2

Exact Mass: 395.06498

Molecular Weight: 395.49

Elemental Analysis: C, 63.77; H, 4.33; N, 3.54; O, 12.14; S, 16.22


Specification:

Synonym: KU 55933; KU55933; KU-55933.

IUPAC/Chemical Name: 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one

InChi Key: XRKYMMUGXMWDAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

SMILES Code: O=C1C=C(N2CCOCC2)OC(C3=C4SC5=C(C=CC=C5)SC4=CC=C3)=C1

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: