CAS 585543-15-3: Losmapimod
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CAS 585543-15-3: Losmapimod

CAS 585543-15-3: Losmapimod, Stock 415g, Assay 99.26%, Off-White powder, EOS Med Chem is big manufacturer of Losmapimod.

Losmapimod

Losmapimod, also know as GW856553 or GW856553X or GSK-AHAB, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases. p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway. Inhibiting these enzymes has been shown to produce antidepressant and antipsychotic effects in animal studies, with the mechanism thought to involve increased neurogenesis probably related to BDNF release.

Product Details:

Name: Losmapimod

CAS#: 585543-15-3

Chemical Formula: C22H26FN3O2

Exact Mass: 383.20091

Molecular Weight: 383.46

Elemental Analysis: C, 68.91; H, 6.83; F, 4.95; N, 10.96; O, 8.348

Specification:

Synonym: Losmapimod; GW856553; GW-856553; GW 856553; GSK-AHAB;

IUPAC/Chemical Name: 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide.

InChi Key: KKYABQBFGDZVNQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)

SMILES Code: O=C(C1=CC=C(C2=CC(C(NC3CC3)=O)=CC(F)=C2C)N=C1)NCC(C)(C)C

Appearance: white solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: