CAS 552325-73-2 : A-674563

CAS 552325-73-2 : A-674563
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  • CAS Number: 552325-73-2
  • Stock: 268g
  • Assay: 99.20%

A-674563

A-674563, CAS 552325-73-2, Stock 268g, Assay 99.20%, Off-white or White powder, EOS Med Chem is big manufacturer of A-674563.


A-674563

A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively. A-674563 could contribute to culture conditions that expand chondrocytes without losing chondrocytic characters, and was significantly more effective at reducing NSCLC cell survival relative to the pan-AKT inhibitor MK-2206.


Product Details:

Name: A-674563

CAS#: 552325-73-2

Chemical Formula: C22H22N4O

Exact Mass: 358.17936

Molecular Weight: 358.43628

Elemental Analysis: C, 73.72; H, 6.19; N, 15.63; O, 4.46


Specification:

Synonym: A674563; A 674563; A-674563

IUPAC/Chemical Name: (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine

InChi Key: BPNUQXPIQBZCMR-IBGZPJMESA-N

InChi Code: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1

SMILES Code: N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(NN=C4C)C=C3)=CN=C2

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: