CAS 53552-05-9: (−)-Bicuculline methochloride

CAS 53552-05-9: (−)-Bicuculline methochloride
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  • CAS Number: 53552-05-9
  • Stock: 268g
  • Assay: 99.20%

(−)-Bicuculline methochloride, CAS 53552-05-9

(−)-Bicuculline methochloride, CAS 53552-05-9, Stock 268g, Assay 99.20%, Off-white or White powder, EOS Med Chem is big manufacturer of (−)-Bicuculline methochloride.


(−)-Bicuculline methochloride

(−)-Bicuculline methochloride is an enantiomer of the GABA antagonist (+)-bicuculline methochloride. It increases the firing rate in rat cortical neurons similar to the (+) isomer but lacks GABA antagonist activity. (–)-Bicuculline methochloride inhibits sodium-independent GABA receptor binding with an IC50 value of 500 μM, which is approximately 100-fold less potent than (+)-bicuculline methochloride, but there is no stereoselectivity for sodium-dependent GABA receptor binding.


Product Details:

Name: (−)-Bicuculline methochloride

CAS#: 53552-05-9

Chemical Formula: C21H20ClNO6

Exact Mass: 417.0979

Molecular Weight: 417.84

Elemental Analysis: C, 60.37; H, 4.82; Cl, 8.48; N, 3.35; O, 22.97


Specification:

Synonym: (−)-Bicuculline methochloride

IUPAC/Chemical Name: (5R)-5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium, monochloride

InChi Key: RLJKFAMYSYWMND-VOMIJIAVSA-M

InChi Code: InChI=1S/C21H20NO6.ClH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m1./s1

SMILES Code: O=C(O1)C2=C(C=CC3=C2OCO3)[C@@]1([H])[C@@]4([H])C5=CC6=C(OCO6)C=C5CC[N+]4(C)C.[Cl-]

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: