CAS 2851885-95-3: ARV-393

CAS 2851885-95-3: ARV-393, Stock 720g, Assay 98.85%, White powder, Water 0.24%, Single Impurity 0.16%.

ARV-393

ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.

Product Details:

Name: ARV-393

CAS#: 2851885-95-3

Chemical Formula: C46H53ClFN9O7

Molecular Weight: 898.42

Specification:

SMILES Code: ClC1=CN=C(N2CCC(O[C@@H]3C[C@@H](N4CCC(C5=C(F)C(CN(C6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)C3)CC2)N=C1NC8=CC(C=C(OCC(NC)=O)C(N9C(C)C)=O)=C9C=C8

Appearance: White  powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Room temperature in continental US; may vary elsewhere.

Storage Condition: Please store the product under the recommended conditions in the Certificate of Analysis.

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001