CAS 2296729-00-3: Sotorasib/AMG-510
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CAS Number: 2296729-00-3
Stock: 846g
Assay: 98.60%

Sotorasib/AMG-510, CAS 2296729-00-3

Sotorasib/AMG-510, CAS 2296729-00-3, Stock 846g, Assay 98.6%, White powder, Water 0.24%, Single Impurity 0.32%.

Sotorasib/AMG-510

AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells. Note: According to Sci-Finder database, CAS#2252403-56-6 is a AMG510 active atropisomer. Many vendor mistakenly listed CAS#2296729-00-3 as the AMG510 active atropisomer.

Product Details:

Name: AMG510 HCl
CAS#: Unknown (HCl)
Chemical Formula: C30H31ClF2N6O3
Exact Mass: 560.2347
Molecular Weight: 597.06
Elemental Analysis: C, 60.35; H, 5.23; Cl, 5.94; F, 6.36; N, 14.08; O, 8.04

Specification:

Related CAS #: 2296729-00-3 (racemate) 2252403-56-6 2296729-66-1 2387559-45-5 Unknown (HCl)
Synonym: AMG510; AMG-510; AMG 510; AMG510 HCl; AMG510 hydrochloride;
IUPAC/Chemical Name: 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one hydrochloride
InChi Key: NXQKSXLFSAEQCZ-SFHVURJKSA-N
InChi Code: InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
SMILES Code: O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(O)C=CC=C4F)=C(F)C=C3C(N5[C@@H](C)CN(C(C=C)=O)CC5)=N1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO