CAS 2172875-40-8: Paltusotine HCl

  • CAS 2172875-40-8: Paltusotine HCl

CAS 2172875-40-8: Paltusotine HCl
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  • CAS Number: 2172875-40-8
  • Stock: 76g
  • Assay: 99.15%

Paltusotine HCl, CAS: 2172875-40-8

Paltusotine HCl, CAS: 2172875-40-8, Stock 76g, Assay 99.15%, White powder, EOS is one of TOP GMP manufacturer


Paltusotine

Paltusotine, also known as CRN00808, is a somatostatin receptor agonist. Paltusotine showed no direct inhibition of major cytochrome P450 enzymes or the hERG ion channel and had sufficient exposure in rats and excellent exposure in dogs upon oral dosing. In pharmacodynamic studies, Paltusotine dose-dependently suppressed growth hormone (GH) secretion induced by an exogenous growth-hormone-releasing hormone (GHRH) challenge in both male and female rats following a single oral dose and suppressed IGF-1 levels with repeated oral administration in both rats and dogs.


Product Details:

Name: Paltusotine HCl

CAS#: 2172875-40-8 (2HCl)

Chemical Formula: C27H24Cl2F2N4O

Exact Mass:

Molecular Weight: 529.41

Elemental Analysis: C, 61.26; H, 4.57; Cl, 13.39; F, 7.18; N, 10.58; O, 3.02


Specification:

Related CAS #: 2361216-83-1 (HCl); 2172870-89-0 (free base)   2172875-40-8 (2HCl)    

Synonym: Paltusotine hydrochloride; Paltusotine HCl; Paltusotine; CRN00808; CRN-00808; CRN 00808;

IUPAC/Chemical Name: Benzonitrile, 3-(4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl)-2-hydroxy-, hydrochloride (1:2)

InChi Key: GVTGYFQUBMBIAE-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H22F2N4O.2ClH/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33;;/h1-5,10-13,15,21,34H,6-9,31H2;2*1H

SMILES Code: N#CC1=CC=CC(C2=CC=C3N=CC(C4=CC(F)=CC(F)=C4)=C(N5CCC(N)CC5)C3=C2)=C1O.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Code: 2934.99.9001


Certification: