CAS 2166616-75-5 : LY-3381916
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- CAS Number: 2166616-75-5
- Stock: 75g
- Assay: 99.70%
LY-3381916, CAS 2166616-75-5
LY-3381916, CAS 2166616-75-5, Stock 75g, Assay 99.70%, White powder.
LY-3381916
LY-3381916, also known as IDO1-IN-5, is a potent, selective and brain penetrated DO1 inhibitor. LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
Product Details
Name: LY-3381916
CAS#: 2166616-75-5 (free base)
Chemical Formula: C23H25FN2O3
Exact Mass: 396.1849
Molecular Weight: 396.4624
Elemental Analysis: C, 69.68; H, 6.36; F, 4.79; N, 7.07; O, 12.11
Specification:
Related CAS #: LY3381916 HCl 2166616-75-5 (free base)
Synonym: LY-3381916; LY 3381916; LY 3381916; IDO1-IN-5; IDO1-IN-5; IDO1 IN-5; IDO1-IN5; IDO1IN5; IDO1 IN5;
IUPAC/Chemical Name: (R)-4-fluoro-N-(1-(1-(tetrahydro-2H-pyran-4-carbonyl)indolin-5-yl)ethyl)benzamide
InChi Key: NUBWFWVVKLRSHS-OAHLLOKOSA-N
InChi Code: InChI=1S/C23H25FN2O3/c1-15(25-22(27)16-2-5-20(24)6-3-16)18-4-7-21-19(14-18)8-11-26(21)23(28)17-9-12-29-13-10-17/h2-7,14-15,17H,8-13H2,1H3,(H,25,27)/t15-/m1/s1
SMILES Code: FC1=CC=C(C(N[C@H](C)C2=CC=C(N(C(C3CCOCC3)=O)CC4)C4=C2)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Certifications:
