CAS 215802-15-6 : SB269652

CAS 215802-15-6 : SB269652
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  • CAS Number: 215802-15-6
  • Stock: 20g
  • Assay: 98.77%

SB269652, CAS 215802-15-6

SB269652, CAS 215802-15-6, Stock 20g, Assay 98.77%, White powder.


SB269652

SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R). SB269652  binds in a bitopic manner at one protomer of a D2R dimer and modulates the binding of dopamine at a second protomer. Dr. Roberto Maggio's group at University of L'Aquila first domonstrated the allosteric nature of SB269652. This drug potently (low nanomolar range) abolished specific binding of [(3)H]nemanopride and [(3)H]spiperone to Chinese hamster ovary-transfected D(3) receptors when radioligands were used at 0.2 and 0.5 nM, respectively.


Product Details:

Name: SB269652

CAS#: 215802-15-6

Chemical Formula: C27H30N4O

Exact Mass: 426.24196

Molecular Weight: 426.56

Elemental Analysis: C, 76.03; H, 7.09; N, 13.13; O, 3.75


Specification:

Synonym: SB269652; SB-269652; SB2 69652; SB269,652; SB-269,652; SB 269,652.

IUPAC/Chemical Name: N-((1r,4r)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide

InChi Key: JGLGOAQPUQITLD-OGAOHHHESA-N

InChi Code: InChI=1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-

SMILES Code: O=C(C(N1)=CC2=C1C=CC=C2)N[C@H]3CC[C@H](CCN4CC5=C(C=CC(C#N)=C5)CC4)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: