Bomedemstat ditosylate,CAS 1990504-72-7

Bomedemstat ditosylate,CAS 1990504-72-7, Stock 105g, Assay 98.97%, White powder, Water 0.20%, Single Impurity 0.24%.

Bomedemstat ditosylate

Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antagonist BCLXL.

Product Details:

Name: Bomedemstat ditosylate

CAS#: 1990504-72-7 (tosylate)

Chemical Formula: C42H50FN7O8S2

Exact Mass: 863.31

Molecular Weight: 864.021

Elemental Analysis: C, 58.39; H, 5.83; F, 2.20; N, 11.35; O, 14.81; S, 7.42

Specification:

Synonym: IMG-7289 ditosylate; IMG 7289; IMG7289; Bomedemstat ditosylate;

IUPAC/Chemical Name: N-((2S)-5-(((1R,2S)-2-(4-Fluorophenyl)cyclopropyl)amino)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl)-4-(1H-1,2,3-triazol-1-yl)benzamide bis-tosylate salt

InChi Key: WLRWBXFBIJMKHG-DVNXTAPYSA-N

InChi Code: InChI=1S/C28H34FN7O2.2C7H8O3S/c1-34-15-17-35(18-16-34)28(38)25(3-2-12-30-26-19-24(26)20-4-8-22(29)9-5-20)32-27(37)21-6-10-23(11-7-21)36-14-13-31-33-36;2*1-6-2-4-7(5-3-6)11(8,9)10/h4-11,13-14,24-26,30H,2-3,12,15-19H2,1H3,(H,32,37);2*2-5H,1H3,(H,8,9,10)/t24-,25-,26+;;/m0../s1

SMILES Code: O=C(N[C@@H](CCCN[C@H]1[C@H](C2=CC=C(F)C=C2)C1)C(N3CCN(C)CC3)=O)C4=CC=C(N5N=NC=C5)C=C4.OS(=O)(C6=CC=C(C)C=C6)=O.OS(=O)(C7=CC=C(C)C=C7)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: