CAS 152946-68-4: Nolatrexed HCl
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Nolatrexed HCl, CAS 152946-68-4

Nolatrexed HCl, CAS 152946-68-4, Stock 430g, Assay 99.24%, Off-White powder, EOS Med Chem is big manufacturer of Nolatrexed HCl.

Nolatrexed HCl

Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Hence, it does not warrant further study as a single agent for this disease.

Product Details:

Name: Nolatrexed HCl

CAS#: 152946-68-4 (HCl salt)

Chemical Formula: C14H14Cl2N4OS

Exact Mass: 356.0265

Molecular Weight: 357.25

Elemental Analysis: C, 47.07; H, 3.95; Cl, 19.85; N, 15.68; O, 4.48; S, 8.97

Specification:

Synonym: AG337; AG 337; AG-337; Nolatrexed HCl; Nolatrexed dihydrochloride; brand name: Thymitaq.

IUPAC/Chemical Name: 2-Amino-6-methyl-5-(4-pyridylthio)-1H-quinazolin-4-one dihydrochloride

InChi Key: PJKVJJYMWOCLIJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H

SMILES Code: O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >99.24% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: