CAS 1297537-33-7: Ketodarolutamide

  • CAS 1297537-33-7: Ketodarolutamide

CAS 1297537-33-7: Ketodarolutamide
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  • CAS Number: 1297537-33-7
  • Stock: 229g
  • Assay: 99.33%

Ketodarolutamide, CAS 1297537-33-7

Ketodarolutamide, CAS 1297537-33-7, Stock 229g, Assay 99.33%, White powder, Water 0.39%, Single Impurity 0.28%.


Ketodarolutamide

Ketodarolutamide., also known as ORM-15341 and BAY-1896953, is a potent and full antagonist for human AR (hAR) with IC50 = 38 nM. Ketodarolutamide is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of darolutamide (ODM-201, BAY-1841788), an NSAA which is used in the treatment of prostate cancer in men. Similarly to its parent compound, darolutamide acts as a highly selective, high-affinity, competitive silent antagonist of the androgen receptor (AR). Both agents show much higher affinity and more potent inhibition of the AR relative to the other NSAAs enzalutamide and apalutamide, although they also possess much shorter and comparatively less favorable elimination half-lives.


Product Details:

Name: Ketodarolutamide

CAS#: 1297537-33-7

Chemical Formula: C19H17ClN6O2

Exact Mass: 396.1102

Molecular Weight: 396.835

Elemental Analysis: C, 57.51; H, 4.32; Cl, 8.93; N, 21.18; O, 8.06


Specification:

Synonym: BAY-1896953; BAY 1896953; BAY1896953; ORM-15341; ORM 15341; ORM15341; Ketodarolutamide;

IUPAC/Chemical Name: (S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

InChi Key: GMBPVBVTPBWIKC-NSHDSACASA-N

InChi Code: InChI=1S/C19H17ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-/m0/s1

SMILES Code: ClC1=C(C#N)C=CC(C2=NN(C[C@H](C)NC(C3=NNC(C(C)=O)=C3)=O)C=C2)=C1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: