CAS 1286739-19-2: FRAX597

  • CAS 1286739-19-2: FRAX597

CAS 1286739-19-2: FRAX597
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  • CAS Number: 1286739-19-2
  • Stock: 348g
  • Assay: 99.38%

FRAX597, CAS 1286739-19-2

FRAX597, CAS 1286739-19-2, Stock 348g, Assay 99.38%, White powder, Water 0.35%, Single Impurity 0.27%.


FRAX597

FRAX597 is a potent and selective inhibitor of the p21-activated kinases. FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP-competitive Group I PAK inhibitors with significant potential for the treatment of NF2 and other cancers.


Product Details:

Name: FRAX597

CAS#: 1286739-19-2

Chemical Formula: C29H28ClN7OS

Exact Mass: 557.17646

Molecular Weight: 558.1

Elemental Analysis: C, 62.41; H, 5.06; Cl, 6.35; N, 17.57; O, 2.87; S, 5.74


Specification:

Synonym: FRAX597; FRAX-597; FRAX 597.

IUPAC/Chemical Name: 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one

InChi Key: DHUJCQOUWQMVCG-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H28ClN7OS/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34)

SMILES Code: O=C1C(C2=CC=C(C3=CN=CS3)C=C2Cl)=CC4=CN=C(NC5=CC=C(N6CCN(C)CC6)C=C5)N=C4N1CC

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: