CAS 1276553-09-3 : PF-4989216

CAS 1276553-09-3 : PF-4989216
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  • CAS Number: 1276553-09-3
  • Stock: 367g
  • Assay: 99.39%

PF-4989216, CAS 1276553-09-3

PF-4989216, CAS 1276553-09-3, Stock 367g, Assay 99.39%, White powderWater 0.21%, Single Impurity 0.40%.


PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads to inhibition in cell proliferation and xenograft tumor growth in NSCLCs harboring a PIK3CA mutation, including an erlotinib resistant line, NCI-H1975. PF-4989216 inhibited PI3K downstream signaling and subsequently led to apoptosis induction, and inhibition in cell viability, transformation, and xenograft tumor growth in SCLCs harboring PIK3CA mutation.

Product Details:

Name: PF-4989216

CAS#: 1276553-09-3

Chemical Formula: C18H13FN6OS

Exact Mass: 380.08556

Molecular Weight: 380.39882

Elemental Analysis: C, 56.83; H, 3.44; F, 4.99; N, 22.09; O, 4.21; S, 8.43


Synonym: PF4989216; PF 4989216; PF-4989216.

IUPAC/Chemical Name: 4-(4-cyano-2-fluorophenyl)-2-morpholino-5-(1H-1,2,4-triazol-5-yl)thiophene-3-carbonitrile


InChi Code: InChI=1S/C18H13FN6OS/c19-14-7-11(8-20)1-2-12(14)15-13(9-21)18(25-3-5-26-6-4-25)27-16(15)17-22-10-23-24-17/h1-2,7,10H,3-6H2,(H,22,23,24)


Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001