CAS 127-31-1: Fludrocortisone
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Fludrocortisone, CAS 127-31-1

Fludrocortisone, CAS 127-31-1, Stock 842g, Assay 99.32%, White powder, Water 0.31%, Single Impurity 0.37%.

Fludrocortisone

Fludrocortisone is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. Therapeutically, it is used for its mineralocorticoid activity and not for its glucocorticoid activity. Fludrocortisone has been used in the treatment of cerebral salt wasting syndrome. However, it is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. Due to its effects on increasing Na+ levels, and therefore blood volume, fludrocortisone is the first line of treatment for orthostatic intolerance and postural orthostatic tachycardia syndrome (POTS). It can be used to treat low blood pressure. Fludrocortisone is also used as a confirmation test for diagnosing Conn's syndrome (aldosterone producing-adrenal adenoma).

Product Details:

Name: Fludrocortisone

CAS#: 127-31-1 (free)

Chemical Formula: C21H29FO5

Exact Mass: 380.1999

Molecular Weight: 380.4504

Elemental Analysis: C, 66.30; H, 7.68; F, 4.99; O, 21.03

Specification:

Synonym: Fludrocortisone, Astonin, 9α-fluorocortisol, 9α-fluorohydrocortisone, Florinef, Fludrocortisone acetate

IUPAC/Chemical Name: (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

InChi Key: AAXVEMMRQDVLJB-BULBTXNYSA-N

InChi Code: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

SMILES Code: C[C@]12CCC(C=C1CC[C@@H]3[C@]2(F)[C@@H](O)C[C@@]4(C)[C@H]3CC[C@]4(O)C(CO)=O)=O

Appearance: White to light yellow crystalline powder.

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: