CAS 1263373-43-8 : NVP-2
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NVP-2, CAS 1263373-43-8

NVP-2, CAS 1263373-43-8, Stock 439g, Assay 99.32%, White powder, Water 0.48%, Single Impurity 0.20%.

NVP-2

NVP-2 is a strong, remarkably selective CDK9 inhibitor with an equally potent CDK10/CycM inhibitor. NVP-2 represents a highly promising starting point to design analogs that will hopefully inhibit selectively CDK10/CycM. inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases.

Product Details:

Name: NVP-2

CAS#: 1263373-43-8

Chemical Formula: C27H37ClN6O2

Exact Mass: 512.2667

Molecular Weight: 513.083

Elemental Analysis: C, 63.21; H, 7.27; Cl, 6.91; N, 16.38; O, 6.24

Specification:

Synonym: NVP-2; NVP 2; NVP2.

IUPAC/Chemical Name: 4-({[6-(5-chloro-2-{[(1r,4r)-4-{[(2R)-1-methoxypropan-2-yl]amino}cyclohexyl]amino}pyridin-4-yl)pyridin-2-yl]amino}methyl)oxane-4-carbonitrile

InChi Key: XWQVQSXLXAXOPJ-NJDAHSKKSA-N

InChi Code: InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1

SMILES Code: N#CC1(CNC2=NC(C3=CC(N[C@H]4CC[C@H](N[C@H](C)COC)CC4)=NC=C3Cl)=CC=C2)CCOCC1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: