CAS 1252594-99-2: ETP-46321

  • CAS 1252594-99-2: ETP-46321

CAS 1252594-99-2: ETP-46321
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 1252594-99-2
  • Stock: 250g
  • Assay: 99.15%

ETP-46321, CAS 1252594-99-2

ETP-46321, CAS 1252594-99-2, Stock 250g, Assay 99.15%, White powder,EOS Med Chem is big manufacturer of ETP-46321


ETP-46321

ETP-46321 is a potent and orally bioavailable PI3K α, δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP-46321 PK/PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K-Ras(G12V) oncogenic mutation. Treatment with ETP-46321 resulted in significant tumor growth inhibition.


Product Details:

Name: ETP-46321

CAS#: 1252594-99-2

Chemical Formula: C20H27N9O3S

Exact Mass: 473.19576

Molecular Weight: 473.55

Elemental Analysis: C, 50.73; H, 5.75; N, 26.62; O, 10.14; S, 6.77


Specification:

Synonym: ETP46321; ETP-46321; ETP 46321

IUPAC/Chemical Name: 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine

InChi Key: OHKDVDMWRKFZRB-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H27N9O3S/c1-33(30,31)29-4-2-26(3-5-29)12-16-13-28-14-17(15-10-22-20(21)23-11-15)25-19(18(28)24-16)27-6-8-32-9-7-27/h10-11,13-14H,2-9,12H2,1H3,(H2,21,22,23)

SMILES Code: NC1=NC=C(C2=CN3C(C(N4CCOCC4)=N2)=NC(CN5CCN(S(=O)(C)=O)CC5)=C3)C=N1

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: