CAS 1141397-80-9: Cedazuridine

CAS 1141397-80-9: Cedazuridine, Stock 170g, Assay 99.7%, White powder, Water 0.27%, Single Impurity 0.3%.

Cedazuridine

Cedazuridine, also known as E 7727 and WHO 10741, is a cytidine deaminase inhibitor. Decitabine/cedazuridine, sold under the brand name Inqovi, is a fixed-dosed combination medication for the treatment of adults with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). It is a combination of decitabine, a nucleoside metabolic inhibitor, and cedazuridine, a cytidine deaminase inhibitor. Decitabine/cedazuridine was approved for medical use in the United States and in Canada in July 2020.

Product Details:

Name: Cedazuridine

CAS#: 1141397-80-9

Chemical Formula: C9H14F2N2O5

Exact Mass: 268.09

Molecular Weight: 268.210

Elemental Analysis: C, 40.30; H, 5.26; F, 14.17; N, 10.44; O, 29.82

Specification:

Synonym: Cedazuridine; E7727; E-7727; E 7727; WHO 10741; WHO-10741; WHO10741;

IUPAC/Chemical Name: (R)-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one

InChi Key: VUDZSIYXZUYWSC-DBRKOABJSA-N

InChi Code: InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1

SMILES Code: O=C1N([C@H]2C(F)(F)[C@@H]([C@@H](CO)O2)O)CC[C@@H](O)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001