Tovorafenib,CAS 1096708-71-2

Tovorafenib,CAS 1096708-71-2, Stock 450g, Assay 98.80%, Solid powder, Water 0.25%, Single Impurity 0.15%.

Tovorafenib

Tovorafenib. also known as TAK-580, MLN2480, BIIB024, and AMG 2112819, DAY101, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.

Product Details:

Name: Tovorafenib

CAS#: 1096708-71-2

Chemical Formula: C17H12Cl2F3N7O2S

Exact Mass: 505.01

Molecular Weight: 506.290

Elemental Analysis: C, 40.33; H, 2.39; Cl, 14.01; F, 11.26; N, 19.37; O, 6.32; S, 6.33

Specification:

Synonym: AMG 2112819; AMG2112819; AMG2112819; BIIB 024; BIIB 024; BIIB024; BUB 024; BUB024; BUB-024; MLN 2480; MLN2480; MLN-2480; TAK 580; TAK580; TAK-580; DAY101; DAY-101; DAY 101;Tovorafenib;

IUPAC/Chemical Name: (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide

InChi Key: VWMJHAFYPMOMGF-ZCFIWIBFSA-N

InChi Code: InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1

SMILES Code: O=C(C1=CN=C([C@H](NC(C2=NC=NC(N)=C2Cl)=O)C)S1)NC3=NC=C(Cl)C(C(F)(F)F)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001