Defactinib,CAS 1073154-85-4

  • Defactinib,CAS 1073154-85-4

Defactinib,CAS 1073154-85-4
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  • CAS Number: 1073154-85-4
  • Stock: 320g
  • Assay: 99.30%

Defactinib,CAS 1073154-85-4

Defactinib,CAS 1073154-85-4, Stock 320g, Assay 99.3%, White powder, Water 0.15%, Single Impurity 0.30%.


Defactinib

Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.


Product Details:

Name: Defactinib free base

CAS#: 1073154-85-4 (free base)

Chemical Formula: C20H21F3N8O3S

Exact Mass: 510.14

Molecular Weight: 510.490

Elemental Analysis: C, 47.06; H, 4.15; F, 11.16; N, 21.95; O, 9.40; S, 6.28




Specification:

Synonym: VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878; Defactinib

IUPAC/Chemical Name: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

InChi Key: FWLMVFUGMHIOAA-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)

SMILES Code: O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001