CAS 1262238-11-8: INCB3344
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- CAS Number: 1262238-11-8
- Stock: 487g
- Assay: 99.43%
INCB3344, CAS 1262238-11-8
INCB3344, CAS 1262238-11-8, Stock 487g, Assay 99.43%, White powder, Water 0.32%, Single Impurity 0.25%.
INCB3344
INCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100-fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target validation in rodent models.
Product Details:
Name: INCB3344 free base
CAS#: 1262238-11-8 (free base)
Chemical Formula: C29H34F3N3O6
Exact Mass:
Molecular Weight: 577.6012
Elemental Analysis: C, 60.30; H, 5.93; F, 9.87; N, 7.28; O, 16.62
Specification:
Synonym: INCB3344; INCB-3344; INCB 3344.
IUPAC/Chemical Name: N-(2-(((3R,4R)-1-((1s,4S)-4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
InChi Key: MZEOSVPWMSEFPW-OXKSBSDWSA-N
InChi Code: InChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21-,22-,25-,28+/m1/s1
SMILES Code: O=C(NCC(N[C@@H]1CN([C@H]2CC[C@](O)(C3=CC=C(OCO4)C4=C3)CC2)C[C@H]1OCC)=O)C5=CC=CC(C(F)(F)F)=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
