CAS 918407-35-9: Avoralstat
(World's Largest Pharmaceutical Supplier)

CAS Number: 918407-35-9
Stock: 837g
Assay: 98.23%

Avoralstat, CAS 918407-35-9

Avoralstat, CAS 918407-35-9, Stock 837g, Assay 98.23%, White powder, Water 0.57%, Single Impurity 0.82%.

Avoralstat

Avoralstat, also known as BCX-4161, is a potent and orally active Kallikrein inhibitor and Bradykinin inhibitor. Avoralstat may be potentially useful for treatment for Hereditary angioedema. Avoralstat inhibits plasma kallikrein and suppresses bradykinin production. Bradykinin is the mediator of acute swelling attacks in HAE patients.

Product Details:

Name: Avoralstat
CAS#: 918407-35-9
Chemical Formula: C28H27N5O5
Exact Mass: 513.2012
Molecular Weight: 513.554
Elemental Analysis: C, 65.49; H, 5.30; N, 13.64; O, 15.58

Specification:

Synonym: BCX-4161; BCX 4161; BCX4161; Avoralstat

IUPAC/Chemical Name: 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine-2-carboxylic acid

InChi Key: TUWMKPVJGGWGNL-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H27N5O5/c1-3-16-12-21(26(34)32-18-8-6-17(7-9-18)25(29)30)20(13-23(16)38-2)19-10-11-22(33-24(19)28(36)37)27(35)31-14-15-4-5-15/h3,6-13,15H,1,4-5,14H2,2H3,(H3,29,30)(H,31,35)(H,32,34)(H,36,37)

SMILES Code: O=C(C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC(OC)=C(C=C)C=C3C(NC4=CC=C(C(N)=N)C=C4)=O)O

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001