Ganetespib, CAS 888216-25-9
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- CAS Number: 888216-25-9
- Stock: 888g
- Assay: 98.64%
Ganetespib, CAS 888216-25-9
Ganetespib, CAS 888216-25-9, Stock 888g, Assay 98.64%, White powder, Water 0.24%, Single Impurity 0.32%.
STA-9090
Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor STA-9090 binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance.
Product Details:
Name: Ganetespib (STA-9090)
CAS#: 888216-25-9
Chemical Formula: C20H20N4O3
Exact Mass: 364.15354
Molecular Weight: 364.4
Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17
Specification:
Synonym: STA9090; STA 9090; STA-9090; Ganetespib
IUPAC/Chemical Name: 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H- 1,2,4-triazol-3-one
InChi Key: RVAQIUULWULRNW-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)
SMILES Code: O=C1NN=C(C2=CC(C(C)C)=C(O)C=C2O)N1C3=CC4=C(N(C)C=C4)C=C3
Appearance: white powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001