XL-880,Foretinib, CAS 849217-64-7

  • XL-880,Foretinib, CAS 849217-64-7

XL-880,Foretinib, CAS 849217-64-7
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  • CAS Number: 849217-64-7
  • Stock: 991g
  • Assay: 98.61%

XL-880,Foretinib, CAS 849217-64-7

XL-880,Foretinib, CAS 849217-64-7Stock 991g, Assay 98.61%, White powderWater 0.24%, Single Impurity 0.42%.


Foretinib

Foretinib, also known as XL880 and GSK1363089, is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.



Product Details:

Name: Foretinib

CAS#: 849217-64-7 (free base)

Chemical Formula: C34H34F2N4O6

Exact Mass: 632.24464

Molecular Weight: 632.65

Elemental Analysis: C, 64.55; H, 5.42; F, 6.01; N, 8.86; O, 15.17



Specification:

Related CAS #: 1226999-07-0 (phosphate)   849217-64-7 (free base)    

Synonym: XL880; XL 880; XL-880; GSK1363089; GSK 1363089; GSK-1363089; GSK089; EXEL2880; Foretinib.

IUPAC/Chemical Name: N-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

InChi Key: CXQHYVUVSFXTMY-UHFFFAOYSA-N

InChi Code: InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)

SMILES Code: O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=CC=NC5=CC(OCCCN6CCOCC6)=C(OC)C=C45)C(F)=C3

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: