EX-527(S), CAS 848193-68-0

EX-527(S), CAS 848193-68-0, Stock 687g, Assay 98.67%, White powder, Water 0.24%, Single Impurity 0.32%.

EX-527

Selisistat racemate is a racemic mixture of EX-527, an inhibitor of sirtuin 1 (SIRT1; IC50 = 0.098 µM).1 It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.

Product Details:

Name: Selisistat racemate

CAS#: 848193-68-0 (S-isomer)

Chemical Formula: C13H13ClN2O

Exact Mass: 248.0716

Molecular Weight: 248.71

Elemental Analysis: C, 62.78; H, 5.27; Cl, 14.25; N, 11.26; O, 6.43

Specification:

Related CAS #: 848193-69-1 (R-isomer)   848193-68-0 (S-isomer)   49843-98-3 (racemate)    

Synonym: (±)-EX-527; (±)-EX 527; (±)-EX527; Selisistat racemate; Selisistat racemic

IUPAC/Chemical Name: 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

SMILES Code: O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: