PD0332991.HCl, CAS 827022-32-2

  • PD0332991.HCl, CAS 827022-32-2

PD0332991.HCl, CAS 827022-32-2
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 827022-32-2
  • Stock: 1.75kg
  • Assay: 98.75%

PD0332991.HCl, CAS 827022-32-2

PD0332991.HCl, CAS 827022-32-2Stock 1753g, Assay 98.75%, White powderWater 0.34%, Single Impurity 0.64%.


Palbociclib, also known as PD0332991, is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations.

Product Details:

Name: Palbociclib HCl

CAS#: 827022-32-2 (HCl)

Chemical Formula: C24H29N7O2

Exact Mass:

Molecular Weight: 483.99

Elemental Analysis: C, 59.56; H, 6.25; Cl, 7.33; N, 20.26; O, 6.61


Synonym: PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; Palbociclib, brand name: Ibrance

IUPAC/Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride


InChi Code: InChI=1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);1H


Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water and ethanol; slightly soluble in DMSO with warm.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in water or DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001