TGX-221, CAS 663619-89-4

  • TGX-221, CAS 663619-89-4

TGX-221, CAS 663619-89-4
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 663619-89-4
  • Stock: 894g
  • Assay: 98.64%

TGX-221, CAS 663619-89-4

TGX-221, CAS 663619-89-4Stock 894g, Assay 98.64%, White powderWater 0.24%, Single Impurity 0.32%.


 TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit.TGX221 selectively inhibits renal cell carcinoma cells with both VHL and SETD2 mutations and links multiple pathways. TGX221 blocks xenograft tumor growth of prostate cancer in nude mice. TGX221 is a selective inhibitor for ccRCC with both VHL and SETD2 mutations. TGX221 also targeted cancer cells with CDKN2A and PTEN mutations. TGX221 also exhibited significant selectivity in inhibiting cell motility and tumourigenesis of ccRCC cells with VHL and SETD2 mutations. TGX221 is a novel inhibitor with high selectivity for ccRCC with VHL and SETD2 mutations.

Product Details:

Name: TGX-221

CAS#: 663619-89-4

Chemical Formula: C21H24N4O2

Exact Mass: 364.18993

Molecular Weight: 364.44

Elemental Analysis: C, 69.21; H, 6.64; N, 15.37; O, 8.78


Synonym: TGX221; TGX221; TGX 221.

IUPAC/Chemical Name: 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one


InChi Code: InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3


Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001