Genz-123346, CAS 491833-30-8

  • Genz-123346, CAS 491833-30-8

Genz-123346, CAS 491833-30-8
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 491833-30-8
  • Stock: 996g
  • Assay: 98.73%

Genz-123346, CAS 491833-30-8

Genz-123346, CAS 491833-30-8Stock 996g, Assay 98.73%, White powderWater 0.35%, Single Impurity 0.22%.


Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.

Product Details:

Name: Genz-123346

CAS#: 491833-30-8

Chemical Formula: C24H38N2O4

Exact Mass: 418.28316

Molecular Weight: 418.57

Elemental Analysis: C, 68.87; H, 9.15; N, 6.69; O, 15.29


Synonym: Genz123346; Genz-123346; Genz 123346

IUPAC/Chemical Name: N-[(1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide


InChi Code: InChI=1S/C24H38N2O4/c1-2-3-4-5-6-7-10-23(27)25-20(18-26-13-8-9-14-26)24(28)19-11-12-21-22(17-19)30-16-15-29-21/h11-12,17,20,24,28H,2-10,13-16,18H2,1H3,(H,25,27)/t20-,24-/m1/s1


Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001