RMC-6291, CAS 2641998-63-0

RMC-6291, CAS 2641998-63-0, Stock 186g, Assay 98.35%, White powder, Water 0.18%, Single Impurity 0.15%.

RMC-6291

RMC-6291 is an orally bioavailable, covalent KRAS G12C inhibitor. RMC-6291 forms a tri-complex with the intracellular chaperone protein and immunophilin cyclophilin A (CypA) and KRAS G12C(ON). This tri-complex inhibits KRAS G12C(ON)-mediated signaling, which may inhibit tumor cell proliferation. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

Product Details:

Name: RMC-6291

CAS#: 2641998-63-0

Chemical Formula: C55H78FN9O8

Exact Mass: 1,011.60

Molecular Weight: 1,012.280

Elemental Analysis: C, 65.26; H, 7.77; F, 1.88; N, 12.45; O, 12.64

Specification:

Synonym: RMC-6291; RMC-6291; RMC-6291; GTPL12622;

IUPAC/Chemical Name: 1-(4-(dimethylamino)-4-methylpent-2-ynoyl)-N-((2S)-1-(((22S,63S,4S)-11-ethyl-12-(2-((S)-1-methoxyethyl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-morpholina-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluoro-N-methylpiperidine-4-carboxamide

InChi Key: HJNFYLSFWYRSHS-CMZSUCOPSA-N

InChi Code: InChI=1S/C55H78FN9O8/c1-13-64-44-19-18-37-30-40(44)41(48(64)39-16-14-24-57-46(39)36(4)71-12)32-53(5,6)34-73-51(69)42-17-15-25-65(59-42)50(68)43(31-38-33-63(37)28-29-72-38)58-49(67)47(35(2)3)61(11)52(70)55(56)22-26-62(27-23-55)45(66)20-21-54(7,8)60(9)10/h14,16,18-19,24,30,35-36,38,42-43,47,59H,13,15,17,22-23,25-29,31-34H2,1-12H3,(H,58,67)/t36-,38-,42-,43-,47-/m0/s1

SMILES Code: C[C@@H](C1=[C@]([C@](N2CC)=C(C3=C2C=CC4=C3)CC(C)(COC([C@H]5NN(CCC5)C([C@H](C[C@H]6CN4CCO6)NC([C@@H](N(C)C(C7(CCN(CC7)C(C#CC(C)(C)N(C)C)=O)F)=O)C(C)C)=O)=O)=O)C)C=CC=N1)OC

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Shelf Life: >2 years if stored properly

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001