RLY-4008, CAS 2549174-42-5

RLY-4008, CAS 2549174-42-5, Stock 175g, Assay 98.35%, White powder, Water 0.12%, Single Impurity 0.19%.

RLY-4008

Lirafugratinib, also known as RLY-4008, is a tyrosine kinase inhibitor with potential antineoplastic activity. Lirafugratinib binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.

Product Details:

Name: Lirafugratinib

CAS#: 2549174-42-5 (free base)

Chemical Formula: C28H24FN7O2

Exact Mass: 509.20

Molecular Weight: 509.540

Elemental Analysis: C, 66.00; H, 4.75; F, 3.73; N, 19.24; O, 6.28

Specification:

Synonym: Lirafugratinib; RLY-4008; RLY 4008; RLY4008;

IUPAC/Chemical Name: N-[4-(4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylprop-2-enamide

InChi Key: XOQVZSSDIQQUGO-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H24FN7O2/c1-15(2)27(37)35-19-8-5-17(6-9-19)24-22(23-25(30)32-14-33-26(23)36(24)4)18-7-10-21(20(29)13-18)38-28-31-12-11-16(3)34-28/h5-14H,1H2,2-4H3,(H,35,37)(H2,30,32,33)

SMILES Code: C=C(C)C(NC1=CC=C(C2=C(C3=CC=C(OC4=NC=CC(C)=N4)C(F)=C3)C5=C(N)N=CN=C5N2C)C=C1)=O

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Shelf Life: >2 years if stored properly

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001