KT-474, CAS 2432994-31-3

KT-474, CAS 2432994-31-3, Stock347g, Assay 98.55%, White powder, Water 0.14%, Single Impurity 0.16%.

KT-474

 KT-474, also known as KT-I-417 and SAR444656, is an orally bioavailable degrader of IRAK4. KT-474 is a heterobifunctional small-molecule degrader of IRAK4 composed of ligands to the E3 ligase cereblon (CRBN) and IRAK4 joined by a chemical linker. KT-474 forms a ternary complex with CRBN and IRAK4, leading to the ubiquitination and proteasomal degradation of IRAK4. KT-474 potently degraded IRAK4 in lymphocytes and monocytes with the half-maximal degradation concentration in the 1–2 nM range and a maximum degradation of 100%. KT-474 exhibited more potent and stronger downregulation of both R848 (TLR7/8)-induced and lipopolysaccharide (LPS: TLR4)-induced IL-6 and IL-8 production by PBMCs. KT-474 also blocked TLR9-mediated NF-κB activation by CpG-B in B cells, whereas PF-06550833 had no effect

Product Details:

Name: KT-474

CAS#: 2432994-31-3

Chemical Formula: C44H49F2N11O6

Exact Mass: 865.38

Molecular Weight: 865.940

Elemental Analysis: C, 61.03; H, 5.70; F, 4.39; N, 17.79; O, 11.09

Specification:

Synonym: KT-I-417; KT I 417; PROTAC IRAK4 degrader-7; SAR444656; SAR-444656; SAR 444656; KT-474; KT474; KT 474; KYM-001;

IUPAC/Chemical Name: 5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-(4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

InChi Key: NQGKNAVUMAHSQN-PKIOHZLWSA-N

InChi Code: InChI=1S/C44H49F2N11O6/c1-52-39-27(4-2-6-34(39)57(44(52)61)35-11-12-37(58)50-43(35)60)5-3-19-62-30-13-16-53(17-14-30)22-26-7-9-28(10-8-26)56-24-33(38(51-56)40(45)46)48-42(59)32-21-47-55-18-15-36(49-41(32)55)54-23-31-20-29(54)25-63-31/h2,4,6,15,18,21,24,26,28-31,35,40H,7-14,16-17,19-20,22-23,25H2,1H3,(H,48,59)(H,50,58,60)/t26?,28?,29-,31-,35?/m1/s1

SMILES Code: O=C(C1=C2N=C(N3[C@@]4([H])CO[C@@](C4)([H])C3)C=CN2N=C1)NC5=CN(C6CCC(CN7CCC(OCC#CC8=C(C(N9C(CC%10)C(NC%10=O)=O)=CC=C8)N(C)C9=O)CC7)CC6)N=C5C(F)F

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Shelf Life: >2 years if stored properly

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001