15830266 Zotatifin, CAS 2098191-53-6

Zotatifin, CAS 2098191-53-6

  • Zotatifin, CAS 2098191-53-6

Zotatifin, CAS 2098191-53-6
(World's Largest Pharmaceutical Supplier)

  • CAS Number: 2098191-53-6
  • Stock: 95g
  • Assay: 98.30%

Zotatifin, CAS 2098191-53-6

Zotatifin, CAS 2098191-53-6, Stock 95g, Assay 98.3%, White powder, Water 0.07%, Single Impurity 0.06%.


Zotatifin

Zotatifin, also known as eFT226, is a potent and selective inhibitor of eIF4A, is efficacious in preclinical models of lymphoma. eFT226 promotes eIF4A1 binding to specific 5’-UTR polypurine and/or G-quadraplex recognition motifs leading to a selective block in ribosome mRNA scanning. eFT226 shows potent anti-proliferative activity (GI50 < 15 nM) against a panel of B-cell lymphoma cell lines. Treatment with eFT226 leads to coordinated inhibition of MYC, CCND1/3, BCL2 or MCL1 protein expression resulting in significant anti-tumor activity.


Produt Details:

Name: Zotatifin
CAS#: 2098191-53-6
Chemical Formula: C28H29N3O5
Exact Mass: 487.21
Molecular Weight: 487.556
Elemental Analysis: C, 68.98; H, 6.00; N, 8.62; O, 16.41




Specification:

Synonym: zotatifin; eFT226; eFT 226; eFT 226;

IUPAC/Chemical Name: 4-{(5aR,6S,7S,8R,8aS)-7-[(dimethylamino)methyl]-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin- 5a-yl}benzonitrile

InChi Key: QYCXWOACFWMQFO-WZWZCULESA-N

InChi Code: InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1

SMILES Code: N#CC1=CC=C([C@@]2(O3)[C@@](C4=C3C=C(OC)N=C4OC)(O)[C@H](O)[C@H](CN(C)C)[C@H]2C5=CC=CC=C5)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certification: