K-7174-2HCl, CAS 191089-60-8

  • K-7174-2HCl, CAS 191089-60-8

K-7174-2HCl, CAS 191089-60-8
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  • CAS Number: 191089-60-8
  • Stock: 870g
  • Assay: 98.61%

K-7174-2HCl, CAS 191089-60-8

K-7174-2HCl, CAS 191089-60-8Stock 870g, Assay 98.61%, White powderWater 0.29%, Single Impurity 0.32%.


K-7174 is a novel orally active, potent proteasome inhibitor. K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K-7174 is also a GATA-specific inhibitor, which may have potential application in treating anemia of chronic disease.

Product Details:

Name: K-7174-2HCl

CAS#: 191089-60-8 (HCl)

Chemical Formula: C33H50Cl2N2O6

Exact Mass:

Molecular Weight: 640.3

Elemental Analysis: C, 61.77; H, 7.85; Cl, 11.05; N, 4.37; O, 14.96


Related CAS #: 191089-60-8 (HCl)   191089-59-5 (free base)  

Synonym: K7174; K 7174; K-7174; K-7174-2HCl; K-7174 dihydrochloride.

IUPAC/Chemical Name: 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride.


InChi Code: InChI=1S/C33H48N2O6.2ClH/c1-36-28-22-26(23-29(37-2)32(28)40-5)14-9-7-11-16-34-18-13-19-35(21-20-34)17-12-8-10-15-27-24-30(38-3)33(41-6)31(25-27)39-4;;/h9-10,14-15,22-25H,7-8,11-13,16-21H2,1-6H3;2*1H/b14-9+,15-10+;;


Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001