1903763-82-5: Sisunatovir

1903763-82-5: Sisunatovir, Stock 143g, Assay 98.25%, Off-white to white solid.

RV521

Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo.

Product Details:

ame: Sisunatovir free base

CAS#: 1903763-82-5 (free base)

Chemical Formula: C23H22F4N4O

Exact Mass: 446.17

Molecular Weight: 446.450

Elemental Analysis: C, 61.88; H, 4.97; F, 17.02; N, 12.55; O, 3.58

Specification:

Related CAS #: 1903763-83-6 (HCl)   1903763-82-5 (free base)    

Synonym: RV521; RV-521; RV 521; Sisunatovir;

IUPAC/Chemical Name: 1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one

InChi Key: JOPCJJSYRPUEDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2

SMILES Code: O=C1C2(CC2)C3=C(C=C(F)C=C3)N1CC4=NC5=C(N4CCCC(F)(F)F)C=CC(CN)=C5

Appearance: Off-white to white solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: