CC-90009, CAS 1860875-51-9
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CC-90009, CAS 1860875-51-9

CC-90009, CAS 1860875-51-9, Stock 1634g, Assay 98.74%, White powder, Water 0.56%, Single Impurity 0.89%.

CC-90009

CC-90009 is a cereblon modulator. CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. 

Product Details:

Name: CC-90009

CAS#: 1860875-51-9

Chemical Formula: C22H18ClF2N3O4

Exact Mass: 461.0954

Molecular Weight: 461.8498

Elemental Analysis: C, 57.21; H, 3.93; Cl, 7.68; F, 8.23; N, 9.10; O, 13.86

Specification:

Synonym: CC-90009; CC 90009; CC90009; Eragidomide

IUPAC/Chemical Name: 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

InChi Key: PWBHUSLMHZLGRN-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18ClF2N3O4/c23-15-4-2-14(3-5-15)22(24,25)21(32)26-10-12-1-6-16-13(9-12)11-28(20(16)31)17-7-8-18(29)27-19(17)30/h1-6,9,17H,7-8,10-11H2,(H,26,32)(H,27,29,30)

SMILES Code: O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(C4=CC=C(Cl)C=C4)F

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certifications: