Esaxerenone, CAS 1632006-28-0

Esaxerenone, CAS 1632006-28-0, Stock 952g, Assay 98.64%, White powder, Water 0.24%, Single Impurity 0.32%.

CS-3150, XL-550

Esaxerenone, also known as CS-3150, XL-550, is a nonsteroidal antimineralocorticoid which was discovered by Exelixis and is now under development by Daiichi Sankyo Company for the treatment of hypertension, essential hypertension, hyperaldosteronism, and diabetic nephropathies. It acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher affinity for the MR relative to the existing antimineralocorticoids spironolactone and eplerenone.

Product Details:

Name: Esaxerenone

CAS#: 1632006-28-0

Chemical Formula: C22H21F3N2O4S

Exact Mass: 466.1174

Molecular Weight: 466.4752

Elemental Analysis: C, 56.65; H, 4.54; F, 12.22; N, 6.01; O, 13.72; S, 6.87

Specification:

Related CAS #: 1632006-28-0   880780-76-7   1072195-82-4 (+ isomer)   1072195-83-5 (- isomer)    

Synonym: Esaxerenone; CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.

IUPAC/Chemical Name: 1-(2-hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide

InChi Key: NOSNHVJANRODGR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)

SMILES Code: CS(C1=CC=C(NC(C2=CN(CCO)C(C3=CC=CC=C3C(F)(F)F)=C2C)=O)C=C1)(=O)=O

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: