Fezolinetant, CAS 1629229-37-3

Fezolinetant, CAS 1629229-37-3, Stock 984g, Assay 98.65%, White powder, Water 0.22%, Single Impurity 0.38%.

ESN-364

 Fezolinetant, also known as ESN-364, is Neurokinin-3 (NK-3) receptor antagonist which has been optimized for use in women’s health, and is being developed for sex-hormone related disorders such as endometriosis, polycystic ovarian syndrome and uterine fibroids. Fexolinetant allows modulation of the hypothalamic-pituitary gonadal axis with a selective action on hormones relevant to disease. The agent is expected to have greater tolerability than competing products which target GnRH (Gonadotropin-releasing hormone).

Product Details:

Name: Fezolinetant

CAS#: 1629229-37-3

Chemical Formula: C16H15FN6OS

Exact Mass: 358.1012

Molecular Weight: 358.4

Elemental Analysis: C, 53.62; H, 4.22; F, 5.30; N, 23.45; O, 4.46; S, 8.95

Specification:

Synonym: Fezolinetant; ESN-364; ESN 364; ESN364

IUPAC/Chemical Name: (R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

InChi Key: PPSNFPASKFYPMN-SECBINFHSA-N

InChi Code: InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1

SMILES Code: O=C(C1=CC=C(F)C=C1)N2[C@H](C)C3=NN=C(C4=NC(C)=NS4)N3CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: