GLPG-1690(ziritaxestat), CAS 1628260-79-6

GLPG-1690(ziritaxestat), CAS 1628260-79-6, Stock 769g, Assay 98.74%, White powder, Water 0.24%, Single Impurity 0.32%.

GLPG1690

Ziritaxestat, also known as GLPG1690, is a selective autotaxin inhibitor discovered by Galapagos, with potential application in idiopathic pulmonary disease (IPF). In a Phase 1 study in healthy human volunteers, GLPG1690 demonstrated favorable safety and tolerability, as well as a strong pharmacodynamic signal implying target engagement.

Product Details:

Name: Ziritaxestat (GLPG-1690)

CAS#: 1628260-79-6

Chemical Formula: C30H33FN8O2S

Exact Mass: 588.2431

Molecular Weight: 588.71

Elemental Analysis: C, 61.21; H, 5.65; F, 3.23; N, 19.03; O, 5.44; S, 5.45

Specification:

Synonym: GLPG-1690; GLPG 1690; GLPG1690; ziritaxestat.

IUPAC/Chemical Name: 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile

InChi Key: REQQVBGILUTQNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H33FN8O2S/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3

SMILES Code: CCC(N=C1N2C=C(C=C1C)N3CCN(CC3)CC(N4CC(C4)O)=O)=C2N(C)C5=NC(C6=CC=C(C=C6)F)=C(S5)C#N

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: