AZD-8835, CAS 1620576-64-8

  • AZD-8835, CAS 1620576-64-8

AZD-8835, CAS 1620576-64-8
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  • CAS Number: 1620576-64-8
  • Stock: 817g
  • Assay: 98.66%

AZD-8835, CAS 1620576-64-8

AZD-8835, CAS 1620576-64-8, Stock 817g, Assay 98.66%, White powderWater 0.4%, Single Impurity 0.67%.


AZD-8835

AZD8835 is a potent and selective inhibitor of PI3Kalpha and PI3Kdelata with excellent general kinase selectivity. AZD8835 displayed low metabolic turnover and suitable physical properties for oral administration. At the enzyme level, AZD8835 is a potent mixed inhibitor of PI3Kα (IC50 0.0062 μM) and PI3Kδ (IC50 0.0057 μM), with selectivity against PI3Kβ (IC50 0.431 μM) and PI3Kγ (IC50 0.090 μM). In vivo, AZD8835 showed pharmacodynamic modulation of AKT phosphorylation and near complete inhibition of tumour growth (93% tumour growth inhibition) in a murine H1047R PI3Kalpha mutated SKOV-3 xenograft tumour model after chronic oral administration at 25 mg/kg b.i.d. AZD8835, is currently in phase I clinical trials.


Product Details:

Name: AZD8835

CAS#: 1620576-64-8

Chemical Formula: C22H31N9O3

Exact Mass: 469.25499

Molecular Weight: 469.55

Elemental Analysis: C, 56.28; H, 6.65; N, 26.85; O, 10.22


Specification:

Synonym: AZD-8835; AZD 8835; AZD8835.

IUPAC/Chemical Name: 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

InChi Key: ZGRDYKFVDCFJCZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)

SMILES Code: O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Certifications: