BMS-986165, CAS 1609392-27-9

  • BMS-986165, CAS 1609392-27-9

BMS-986165, CAS 1609392-27-9
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  • CAS Number: 1609392-27-9
  • Stock: 1.28kg
  • Assay: 98.39%

BMS-986165, CAS 1609392-27-9

BMS-986165, CAS 1609392-27-9, Stock 1283g, Assay 98.39%, White powderWater 0.11%, Single Impurity 0.24%.


BMS-986165, also known as Deucravacitinib, is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM).

Product Details:

Name: BMS-986165

CAS#: 1609392-27-9 (free base)

Chemical Formula: C20H19D3N8O3

Exact Mass: 425.2003

Molecular Weight: 425.47

Elemental Analysis: C, 56.46; H, 5.92; N, 26.34; O, 11.28


Synonym: BMS-986165; BMS 986165; BMS986165; Deucravacitinib

IUPAC/Chemical Name: 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide


InChi Code: InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)/i1D3

SMILES Code: O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H]

Appearance: White powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001