CAS 1607837-31-9: CCT251921

  • CAS 1607837-31-9: CCT251921

CAS 1607837-31-9: CCT251921
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  • CAS Number: 1607837-31-9
  • Stock: 129g
  • Assay: 98.43%

CCT251921, CAS 1607837-31-9:

CCT251921, CAS 1607837-31-9, Stock 129g, Assay 98.43%, White powder, Water 0.22%, Single Impurity 0.14%.



CCT251921

CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.




Product Details:

Name: CCT251921

CAS#: 1607837-31-9

Chemical Formula: C21H23ClN6O

Exact Mass: 410.1622

Molecular Weight: 410.906

Elemental Analysis: C, 61.38; H, 5.64; Cl, 8.63; N, 20.45; O, 3.89



Specification:

Synonym: CCT251921; CCT-251921; CCT 251921; CAS#1607837-31-9

IUPAC/Chemical Name: 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

InChi Key: VPJXPDLMACOGIZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23ClN6O/c1-27-16-3-2-13(10-14(16)11-26-27)15-12-25-19(23)17(22)18(15)28-8-5-21(6-9-28)4-7-24-20(21)29/h2-3,10-12H,4-9H2,1H3,(H2,23,25)(H,24,29)

SMILES Code: O=C1NCCC12CCN(C3=C(Cl)C(N)=NC=C3C4=CC5=C(N(C)N=C5)C=C4)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: