CAS 156137-99-4 : Rapacuronium Bromide
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Rapacuronium Bromide, CAS 156137-99-4:

Rapacuronium Bromide, CAS 156137-99-4, Stock 37g, Assay 98.13%, White powder, Water 0.12%, Single Impurity 0.21%.

Rapacuronium Bromide, CAS 156137-99-4

Rapacuronium Bromide, also known as Org 9487, is a rapidly acting, non-depolarizing neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them. Due to risk of fatal bronchospasm it was withdrawn from the United States market by Organon on March 27, 2001, less than 2 years after its FDA approval in 1999.

Product Details:

Name: Rapacuronium Bromide

CAS#: 156137-99-4 (bromide)

Chemical Formula: C37H61BrN2O4

Exact Mass:

Molecular Weight: 677.809

Elemental Analysis: C, 65.57; H, 9.07; Br, 11.79; N, 4.13; O, 9.44

Specification:

Related CAS #: 156137-99-4 (bromide)   465499-11-0 (cation)    

Synonym: Org 9487; Org9487; Org-9487; Rapacuronium Bromide, brand name Raplon.

IUPAC/Chemical Name: 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetoxy-10,13-dimethyl-2-(piperidin-1-yl)-17-(propionyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpiperidin-1-ium bromide

InChi Key: LVQTUXZKLGXYIU-GWSNJHLMSA-M

InChi Code: InChI=1S/C37H61N2O4.BrH/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2;/h6,27-33,35H,1,7-25H2,2-5H3;1H/q+1;/p-1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-;/m0./s1

SMILES Code: C=CC[N+]1([C@H]2C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H](N6CCCCC6)C[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@H]2OC(CC)=O)CCCCC1.[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certification: