Voxelotor(GBT440, GTX011), CAS 1446321-46-5

  • Voxelotor(GBT440, GTX011), CAS 1446321-46-5

Voxelotor(GBT440, GTX011), CAS 1446321-46-5
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  • CAS Number: 1446321-46-5
  • Stock: 711g
  • Assay: 98.66%

Voxelotor(GBT440, GTX011), CAS 1446321-46-5

Voxelotor(GBT440, GTX011), CAS 1446321-46-5Stock 711g, Assay 98.66%, White powderWater 0.24%, Single Impurity 0.22%.


Voxelotor

Voxelotor, also known as GBT-440, is a hemoglobin S allosteric modulator. GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.



Product Details:

Name: Voxelotor

CAS#: 1446321-46-5

Chemical Formula: C19H19N3O3

Exact Mass: 337.1426

Molecular Weight: 337.379

Elemental Analysis: C, 67.64; H, 5.68; N, 12.46; O, 14.23



Specification:

Synonym: Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011; Oxbryta.

IUPAC/Chemical Name: 2-hydroxy-6-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)benzaldehyde

InChi Key: FWCVZAQENIZVMY-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3

SMILES Code: O=CC1=C(OCC2=CC=CN=C2C3=CC=NN3C(C)C)C=CC=C1O

Appearance: white powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properl

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001



Certification: