CAS 1421936-85-7: Iclepertin
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CAS 1421936-85-7: Iclepertin  

Newest Small molecule inhibitor：CAS 1421936-85-7: Iclepertin, Stock 25g, Assay 99%, White solid. 

Iclepertin

Iclepertin is a new type of potent and selective GlyT1 inhibitor. By inhibiting GlyT1, preventing the re-uptake of glycine, increasing the glycine concentration in the synaptic cleft, thereby enhancing NMDA receptor signaling and synaptic plasticity, thereby improving schizophrenia. The role of patient cognition in Alzheimer's disease and schizophrenia research.

Product Details:

Product Name: Iclepertin

Cas. No.: 1421936-85-7 

Molecular Formula: C20H18F6N2O5S 

Molecular Weight: 512.42

Specification:

Synonym: Iclepertin; Iclépertine; Iclepertina; Iclepertinum;

IUPAC/Chemical Name: (5-(methylsulfonyl)-2-(((S)-1,1,1-trifluoropropan-2-yl)oxy)phenyl)((1R,5R)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone

InChi Key: MYHDQTVHHMSLEF-FHGNATFXSA-N

InChi Code: InChI=1S/C20H18F6N2O5S/c1-10(19(21,22)23)32-14-4-3-12(34(2,30)31)5-13(14)17(29)28-8-11-7-18(11,9-28)15-6-16(33-27-15)20(24,25)26/h3-6,10-11H,7-9H2,1-2H3/t10-,11-,18-/m0/s1

SMILES Code: O=C(C1=CC(S(=O)(C)=O)=CC=C1O[C@@H](C)C(F)(F)F)N2C[C@@]3(C4=NOC(C(F)(F)F)=C4)C[C@@]3([H])C2

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

HNMR:

HPLC:

Iclepertin Intermediates：